Convocatorias Predoctorales: FPI, FPU, CCAA, Fundaciones

Licenciados/graduados con Máster de 60 ECTS finalizado interesados en desarrollar tesis doctoral en inflamación con contrato 48 meses de Fundación Séneca (http://fseneca.es/seccion/7224) o Ministerio (convocatoria inminente). Se necesitan 3 candidatos:

1. Proyecto basado en uso del pez cebra como modelo preclínico y estudio de muestras humanas de pacientes con inflamación en piel en colaboración con Hospital Universitario Virgen Arrixaca. Se pretende vaidar nuevas dianas terapéuticas y buscar nuevas drogas anti-inflamatorias.
2. Proyecto sobre el papel del TNFa en la especificación de células madre hematopoyéticas usando el pez cebra y células madre embrionarias humanas y ratón.
3. Proyecto sobre el papel de las prostaglandinas en la regulación de la inflamación en peces: modelo de pez cebra y peces de interés en acuicultura.

Publicaciones recientes relacionadas:

MULERO I, SEPULCRE MP, MESEGUER J, GARCIA-AYALA A, MULERO V (2007). Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response. Proc Natl Acad Sci USA. 104: 19434-19439. Full text

ROCA FJ, MULERO I, LOPEZ-MUÑOZ A, SEPULCRE MP, MESEGUER J, MULERO V (2008). Evolution of the inflammatory response in vertebrates: fish TNFa is a powerful activator of endothelial cells but hardly activates phagocytes. J Immunol 181:5071-5081. Full text

SEPULCRE MP, ALCARAZ-PÉREZ F, LÓPEZ-MUÑOZ A, ROCA FJ, MESEGUER J, CAYUELA ML, MULERO V (2009). Evolution of LPS Recognition and Signaling: Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF-kB Activation. J Immunol. 182: 1836-1845 Full text

LÓPEZ-MUÑOZ A, ROCA FJ, MESEGUER J, MULERO V (2009). New insights into the evolution of IFNs: Zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. J Immunol 182: 3440-3449. Full text

OLAVARRÍA VH, SEPULCRE MP, FIGUEROA JE, MULERO V. (2010). Prolactin-induced production of ROS and IL-1b in leukocytes from the bony fish gilthead seabream involves Jak/Stat and NF-kB signaling pathways. J Immunol. 185:3873-3883. Full text

SEPULCRE MP, LÓPEZ-MUÑOZ A, ANGOSTO D, GARCÍA-ALCAZAR A, MESEGUER J, MULERO V (2011). TLR agonists extend the functional lifespan of professional phagocytic granulocytes in the bony fish gilthead seabream and direct precursor differentiation towards the production of granulocytes. Mol. Immunol. 48:846-859. Full text

ANGOSTO D, LÓPEZ-CASTEJÓN G, LÓPEZ-MUÑOZ A SEPULCRE MP, ARIZCUN M, MESEGUER J, MULERO V (2012). Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β. Innate Immun 18:815-824. Full text.

GALINDO-VILLEGAS J, GARCÍA-MORENO D, DE OLIVERIA S, MESEGUER J, MULERO V (2012). Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci USA 109: E2605-E2614. Full text. Full text Author Summary.

COMPAN V, BAROJA-MAZO A, LÓPEZ-CASTEJÓN G, GOMEZ AI, MARTÍNEZ CM, ANGOSTO D, MONTERO MT, HERRANZ AS, BAZÁN E, REIMERS D, MULERO V, PELEGRÍN P (2012). Cell volume regulation modulates NLRP3 inflammasome activation. Immunity 37:487-500. Full text.

ESPÍN R, ROCA FJ, CANDEL S, SEPULCRE MP, GONZÁLEZ-ROSA JM, ALCARAZ-PÉREZ F, MESEGUER J, CAYUELA ML, MERCADER N, MULERO V (2013). TNF receptors regulate vascular homeostasis through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech 6:383-396. Full text.

DE OLIVEIRA S, REYES-ALDASORO CC, CANDEL S, RENSHAW SA, MULERO V, CALADO A. (2013). Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response. J Immunol 190:4349-4359. Full text.

OLAVARRÍA VH, FIGUEROA JE, MULERO V (2013). Induction of genes encoding NADPH oxidase components and activation of interferon regulatory factor-1 by prolactin in fish macrophages. Innate Immun. (in press). Full text.

MUÑOZ I, SEPULCRE MP, MESEGUER J, MULERO V (2013). Molecular cloning, phylogenetic analysis and functional characterization of soluble Toll-like receptor 5 in gilthead seabream, Sparus aurata. Fish Shellfish Immunol 35:36-45. Full text.

Anchelin M, Alcaraz-Pérez F, Martínez CM, Bernabé-García M, Mulero V, Cayuela ML (2013). Premature aging in telomerase-deficient zebrafish. Dis Model Mech. (in press).

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