| | The SMB group is a multidisciplinary group focusing on both the development of advanced optical techniques and their application to the study of a wide range of cellular processes at the nanoscale. The successful candidates will be involved in an __interdisciplinary project__, with research being conducted at the interface between biology and physics. | | The SMB group is a multidisciplinary group focusing on both the development of advanced optical techniques and their application to the study of a wide range of cellular processes at the nanoscale. The successful candidates will be involved in an __interdisciplinary project__, with research being conducted at the interface between biology and physics. |
| - | !!!PROJECT 1. MULTI-GOLGI: New multidisciplinary approaches to investigate intra-Golgi membranetraffic and the functional role of Golgi-membrane lateral compartmentalization. |
+ | !!!PROJECT 1. MULTI-GOLGI: New multidisciplinary approaches to investigate intra-Golgi membrane traffic and the functional role of Golgi-membrane lateral compartmentalization. |
| - | The successful candidate will investigate the mechanisms by which secretory cargoes are processed and transported along the Golgi complex. To reach this goal, we will use a unique multidisciplinary approach combining state-of-the-art molecular and cell biological tools with biophysical modeling. Moreover, the candidate will be exposed to advanced imaging techniques, including superresolution microscopy and single molecule approaches. The project will be carried out in collaboration with worldwide leading groups in cell biology and biophysics, offering the successful candidate the opportunity to benefit by a multidisciplinary and international environment. |
+ | The successful candidate will investigate the mechanisms by which secretory cargoes are processed and transported along the Golgi complex. To reach this goal, we will use a unique multidisciplinary approach combining state-of-the-art __molecular and cell biological tools __with biophysical modeling. Moreover, the candidate will be exposed to advanced imaging techniques, including __superresolution microscopy__ and single molecule approaches. The project will be carried out in __collaboration with worldwide leading groups__ in cell biology and biophysics, offering the successful candidate the opportunity to benefit by a multidisciplinary and international environment. |
| | !!!PROJECT 2. ENLIGHTENING TANGO: Unraveling the biophysical mechanisms of collagen export from the endoplasmic reticulum. | | !!!PROJECT 2. ENLIGHTENING TANGO: Unraveling the biophysical mechanisms of collagen export from the endoplasmic reticulum. |
| - | The goal of this project is to unravel the biophysical mechanisms by which large cargoes, such as collagens, are exported from the ER. In particular, we will study the molecular and biophysical mechanisms by which the ER-resident protein TANGO1 controls collagen export. In collaboration with the lab of Prof. Vivek Malhotra at the CRG, Barcelona, we will merge molecular and cell biology techniques with cuttingedge optical nanoscopy (such as 3D STORM imaging, intracellular single particle tracking) and theoretical biophysics into a unique multidisciplinary approach that will deliver the first structural, dynamic and physical understanding of the pathways involved in collagen secretion. |
+ | The goal of this project is to unravel the __biophysical mechanisms__ by which large cargoes, such as collagens, are exported from the ER. In particular, we will study the molecular and biophysical mechanisms by which the ER-resident protein TANGO1 controls collagen export. In collaboration with the lab of Prof. Vivek Malhotra at the CRG, Barcelona, we will merge molecular and cell biology techniques with __cutting-edge optical nanoscopy __(such as 3D STORM imaging, intracellular single particle tracking) and __theoretical biophysics__ into a unique multidisciplinary approach that will deliver the first structural, dynamic and physical understanding of the pathways involved in collagen secretion. |
| | !!!Eligibility and Conditions | | !!!Eligibility and Conditions |
| | * No restrictions of citizenship apply to the ICFO pre- and post-doctoral contracts. | | * No restrictions of citizenship apply to the ICFO pre- and post-doctoral contracts. |
| - | !!!Application procedure and further information |
+ | !!!Application procedure and further information |
| | Informal science and project-related enquiries are very much welcome, and may be addressed to Dr. Felix Campelo (felix.campelo@icfo.eu). | | Informal science and project-related enquiries are very much welcome, and may be addressed to Dr. Felix Campelo (felix.campelo@icfo.eu). |
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