Contrato Predoctoral: Oferta Tesis Doctoral en el campo de la Biología Estructural

PREDOCTORAL POSITION ON THE STRUCTURAL BIOLOGY OF THE UBIQUITIN/PROTEASOME PATHWAY IN PLANTS

A 3-year predoctoral contract, starting in 2012, is available to work on a project (BIO2011-28184-C02-02) that aims to understand the structural biology of SCF(SKP2A) E3 ligase complex in the ubiquitin/proteasome pathway in plants.

The ubiquitin Proteasome System (UPS) regulates the stability, and therefore the function, of proteins. This pathway is becoming very important in the control of multiple processes during plant development and in the responses to environmental cues, both biotic and abiotic. E3 ubiquitin ligases play a key role in the ubiquitin pathway since they are the enzymes that have to recruit specifically the target proteins for degradation. We would like to understand the molecular mechanism of action of SCF(SKP2A) E3 ligase and its interplay with the phytohormone auxin for cell cycle regulation.

The successful candidate will have the opportunity to acquire extensive knowledge in protein expression and purification, state-of-the-art crystallography and biophysical techniques to study protein-protein and protein-small molecule interactions.

We are looking for a highly motivated predoctoral fellow interested in carrying out a PhD in Structural Biology. The candidate would need to a have a Bachelor or Master degree in Biochemistry (degrees in Biology, Chemistry, Biotechnology or Pharmacy will be also considered) and would have finished his/her studies in 2010 or later, with a minimal final record of 2 out of 4. Expertise in the fields of molecular biology and biochemistry will be highly considered.

Please send your CV to:

María José Sánchez Barrena
Departamento de Cristalografía y Biología Estructural
Instituto de Química Física Rocasolano. CSIC
Serrano 119. 28006 Madrid
http://www.xtal.iqfr.csic.es/
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